Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma

Abstract

One of the characteristic features of anaplastic lymphoma kinase (ALK)+, anaplastic large cell lymphoma (ALK+ALCL) is the constitutive activation of signal transducers and activators of transcription-3 (STAT3), a defect believed to be important for the pathogenesis of these tumors. In this report, we describe the existence of an autocrine stimulatory loop… (More)
DOI: 10.1038/leu.2008.129

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