Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function.

@article{Hunter2002AberrantEO,
  title={Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function.},
  author={Deborah S. Hunter and Michael Klotzb{\"u}cher and Hiroyuki Kugoh and Sheng-Li Cai and Johanna P Mullen and Guidalberto Manfioletti and Ulrike Fuhrman and Cheryl Lyn Walker},
  journal={Cancer research},
  year={2002},
  volume={62 13},
  pages={3766-72}
}
Unregulated proliferation of mesenchymal cells in leiomyomas, lipomas, hamartomas,and other diseases has been linked to the high mobility group (HMGA) family of DNA architectural proteins. HMGA genes are primarily expressed during embryonal development and silenced in adult tissues but can become reactivated in neoplasia as a result of chromosomal rearrangements. Although the genetic data suggesting a role for HMGA proteins in tumorigenesis are compelling, the biological role of these proteins… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 55 references

Benign mesenchymal tumor gene HMGI-C as a diagnostic marker in lymphangioleiomyomatosis (LAM)

R. Foronjy, N. Kolesnikova, +6 authors K. Chada
Am. J. Respir. Crit. Care Med., • 2001

Molecular biology of HMGA proteins : hubs of nuclear function

R. Reeves
2001

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