Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer.

@article{Ge2011AberrantEA,
  title={Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer.},
  author={Zhicheng Ge and Andrew James Sanders and Lin Ye and Wen Jiang},
  journal={Experimental and therapeutic medicine},
  year={2011},
  volume={2 2},
  pages={
          167-172
        }
}
Death receptor-3 (DR3) and death decoy receptor-3 (DcR3) are both members of the tumour necrosis factor receptor (TNFR) superfamily. The TNFR superfamily contains eight death domain-containing receptors, including TNFR1 (also called DR1), Fas (also called DR2), DR3, DR4, DR5, DR6, NGFR and EDAR. Upon the binding of these receptors with their corresponding ligands, the death domain recruits various proteins that mediate both the death and proliferation of cells. Receptor function is negatively… CONTINUE READING

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