Aberrant epigenetic regulation: a central contributor to lung carcinogenesis and a new therapeutic target.

@article{Juergens2013AberrantER,
  title={Aberrant epigenetic regulation: a central contributor to lung carcinogenesis and a new therapeutic target.},
  author={Rosalyn A. Juergens and Charles M Rudin},
  journal={American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting},
  year={2013}
}
Carcinogenesis is driven by a combination of genetic and epigenetic abnormalities. Aberrancies in gene promoter methylation patterns and histone acetylation are associated with silencing of tumor suppressor genes in lung cancer and other solid tumors. Identification of key epigenetic modifications has been shown to be prognostic in early-stage non-small cell lung cancer. Previous clinical trials aimed at modifying the epigenome with single-agent demethylating agents or histone deacetylase… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS