Aberrant epigenetic gene regulation in lymphoid malignancies.

  title={Aberrant epigenetic gene regulation in lymphoid malignancies.},
  author={Kristen H. Taylor and Aaron Briley and Zheng Wang and Jianlin Cheng and Huidong Shi and Charles William Caldwell},
  journal={Seminars in hematology},
  volume={50 1},
In lymphoid malignancies, aberrant epigenetic mechanisms such as DNA methylation and histone modifications influence chromatin architecture and can result in altered gene expression. These alterations commonly affect genes that play important roles in the cell cycle, apoptosis, and DNA repair in non-Hodgkin lymphoma (NHL). The ability to identify epigenetic modifications to these important genes has increased exponentially due to advances in technology. As a result, there are well-defined, gene… CONTINUE READING
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