Aberrant coagulation causes a hyper-inflammatory response in severe influenza pneumonia

@article{Yang2016AberrantCC,
  title={Aberrant coagulation causes a hyper-inflammatory response in severe influenza pneumonia},
  author={Yan Chun Yang and Hong Tang},
  journal={Cellular & Molecular Immunology},
  year={2016},
  volume={13},
  pages={432-442}
}
Influenza A virus (IAV) infects the respiratory tract in humans and causes significant morbidity and mortality worldwide each year. Aggressive inflammation, known as a cytokine storm, is thought to cause most of the damage in the lungs during IAV infection. Dysfunctional coagulation is a common complication in pathogenic influenza, manifested by lung endothelial activation, vascular leak, disseminated intravascular coagulation and pulmonary microembolism. Importantly, emerging evidence shows… CONTINUE READING
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