Aberrant circulating levels of purinergic signaling markers are associated with several key aspects of peripheral atherosclerosis and thrombosis.

@article{Jalkanen2015AberrantCL,
  title={Aberrant circulating levels of purinergic signaling markers are associated with several key aspects of peripheral atherosclerosis and thrombosis.},
  author={Juho Jalkanen and Gennady G Yegutkin and Maija Hollm{\'e}n and Kristiina Aalto and Tuomas O Kiviniemi and Veikko V Salomaa and Sirpa Jalkanen and Harri Hakovirta},
  journal={Circulation research},
  year={2015},
  volume={116 7},
  pages={1206-15}
}
RATIONALE Purinergic signaling plays an important role in inflammation and vascular integrity, but little is known about purinergic mechanisms during the pathogenesis of atherosclerosis in humans. OBJECTIVE The objective of this study is to study markers of purinergic signaling in a cohort of patients with peripheral artery disease. METHODS AND RESULTS Plasma ATP and ADP levels and serum nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/CD39) and ecto-5'-nucleotidase/CD73 activities… CONTINUE READING
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