Aberrant chromosome morphology in human cells defective for Holliday junction resolution

@article{Wechsler2011AberrantCM,
  title={Aberrant chromosome morphology in human cells defective for Holliday junction resolution},
  author={Thomas Wechsler and Scott Newman and Stephen C West},
  journal={Nature},
  year={2011},
  volume={471},
  pages={642-646}
}
In somatic cells, Holliday junctions can be formed between sister chromatids during the recombinational repair of DNA breaks or after replication fork demise. A variety of processes act upon Holliday junctions to remove them from DNA, in events that are critical for proper chromosome segregation. In human cells, the BLM protein, inactivated in individuals with Bloom’s syndrome, acts in combination with topoisomerase IIIα, RMI1 and RMI2 (BTR complex) to promote the dissolution of double Holliday… CONTINUE READING

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