Aberrant cerebellar development of transgenic mice expressing dominant-negative thyroid hormone receptor in cerebellar Purkinje cells.

@article{Yu2015AberrantCD,
  title={Aberrant cerebellar development of transgenic mice expressing dominant-negative thyroid hormone receptor in cerebellar Purkinje cells.},
  author={Lu Yu and Toshiharu Iwasaki and Ming Xu and Ronny Lesmana and Yu Xiong and Noriaki Shimokawa and William Wei Lim Chin and Noriyuki Koibuchi},
  journal={Endocrinology},
  year={2015},
  volume={156 4},
  pages={1565-76}
}
To study the role of the thyroid hormone (TH) in cerebellar development, we generated transgenic mice expressing a dominant-negative TH receptor (TR) in cerebellar Purkinje cells. A mutant human TRβ1 (G345R), which binds to the TH-response element but cannot bind to T3, was subcloned into exon 4 of the full-length L7/Pcp-2 gene, which is specifically expressed in Purkinje and retinal rod bipolar cells. The transgene was specifically expressed in Purkinje cells in the postnatal cerebellum… CONTINUE READING
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