Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.

@article{Park2007AberrantAO,
  title={Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.},
  author={Eun Jeong Park and J Rodrigo Mora and Christopher V. Carman and Jian Chen and Yoshiteru Sasaki and Guiying Cheng and Ulrich H von Andrian and Motomu Shimaoka},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 9},
  pages={2526-38}
}
Integrin adhesion molecules mediate lymphocyte migration and homing to normal and inflamed tissues. While the ligand-binding activity of integrins is known to be modulated by conformational changes, little is known about how the appropriate balance of integrin adhesiveness is maintained in order to optimize the migratory capacity of lymphocytes in vivo. In this study we examined the regulation of the gut homing receptor alpha4beta7 integrin by manipulating at the germline level an integrin… CONTINUE READING

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