Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis.

@article{Windish2009AberrantTS,
  title={Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis.},
  author={Hillarie Plessner Windish and Philana Ling Lin and Joshua T Mattila and Angela M. Green and Ezenwa Obi Onuoha and Lawrence P Kane and JoAnne L. Flynn},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={86 3},
  pages={713-25}
}
Foxp3+ T regulatory cells are required to prevent autoimmune disease, but also prevent clearance of some chronic infections. While natural T regulatory cells are produced in the thymus, TGF-beta1 signaling combined with T-cell receptor signaling induces the expression of Foxp3 in CD4+ T cells in the periphery. We found that ICAM-1-/- mice have fewer T… CONTINUE READING