Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia

  title={Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia},
  author={Deborah Bongiovanni and Valentina Saccomani and Erich Piovan},
  booktitle={International journal of molecular sciences},
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant transformation of immature progenitors primed towards T-cell development. Clinically, T-ALL patients present with diffuse infiltration of the bone marrow by immature T-cell blasts high blood cell counts, mediastinal involvement, and diffusion to the central nervous system. In the past decade, the genomic landscape of T-ALL has been the target of intense research. The identification of specific genomic… CONTINUE READING
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