Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer

  title={Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer},
  author={Isabel L{\'o}pez de Silanes and Mar{\'i}a Paz Quesada and Manel Esteller},
  booktitle={Cellular oncology : the official journal of the International Society for Cellular Oncology},
The messenger RNA 3'-untranslated region (3'UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3'UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3'UTR regulatory sequences as well as the aberrant levels… CONTINUE READING
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