Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma

Abstract

Glycosylation abnormalities have been observed in autoimmune diseases and cancer. Here, we compare mechanisms of aberrant O-glycosylation, i.e., formation of Tn and sialyl-Tn structures, on MUC1 in breast cancer, and on IgA1 in an autoimmune disease, IgA nephropathy. The pathways of aberrant O-glycosylation, although different for MUC1 and IgA1, include… (More)
DOI: 10.1007/s00018-012-1082-6

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Cite this paper

@article{Horynov2012AberrantOA, title={Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma}, author={Milada Stuchlov{\'a} Horynov{\'a} and Milan Ra{\vs}ka and Henrik Brink Clausen and Jan Nov{\'a}k}, journal={Cellular and Molecular Life Sciences}, year={2012}, volume={70}, pages={829-839} }