Aberrant NF-B signaling in lymphoma : mechanisms , consequences , and therapeutic implications

@inproceedings{Jost2007AberrantNS,
  title={Aberrant NF-B signaling in lymphoma : mechanisms , consequences , and therapeutic implications},
  author={Philipp J Jost and Juergen Ruland},
  year={2007}
}
The transcription factor NFB is a tightly regulated positive mediator of Tand Bcell development, proliferation, and survival. The controlled activity of NFB is required for the coordination of physiologic immune responses. However, constitutive NFB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma. Various molecular events lead to deregulation of NFB signaling in Hodgkin disease and a variety of… CONTINUE READING
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