Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors

  title={Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors},
  author={Martin Hasselblatt and Joerg Muehlisch and Brigitte Wrede and Birgit Kallinger and Astrid Jeibmann and Ove Peters and Tezer Kutluk and Johannes Ernst Alexander Wolff and W. Paulus and Michael Christoph Fr{\"u}hwald},
  journal={Journal of Neuro-Oncology},
Aberrant methylation of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene is a predictive marker for the response to chemotherapy with alkylating agents (e.g., temozolomide) in malignant gliomas. Since temozolomide is considered for the treatment of choroid plexus tumors, MGMT promoter methylation status was retrospectively assessed in 36 choroid plexus tumors using methylation specific PCR, combined bisulfite restriction analysis (COBRA), and clone sequencing. By methylation… CONTINUE READING


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An interim report of the International CPT-SIOP-2000

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