Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis.

@article{Ercan2010AberrantIG,
  title={Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis.},
  author={Altan Ercan and Jing Cui and Dereck E. W. Chatterton and Kevin D. Deane and Melissa M Hazen and William Brintnell and Colin I. O'Donnell and Lezlie A. Derber and Michael E. Weinblatt and Nancy A. Shadick and David A. Bell and Ewa Cairns and Daniel H. Solomon and V. Michael Holers and Pauline M. Rudd and David M Lee},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 8},
  pages={2239-48}
}
OBJECTIVE To examine the association between aberrant IgG galactosylation and disease parameters in rheumatoid arthritis (RA). METHODS Analysis of N-glycan in serum samples from multiple cohorts was performed. The IgG N-glycan content and the timing of N-glycan aberrancy relative to disease onset were compared in healthy subjects and in patients with RA… CONTINUE READING