Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction.

  title={Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction.},
  author={Andr{\'e} Lacroix and Isabelle Bourdeau and Antoine Lampron and T{\^a}nia Longo Mazzuco and Johanne Tremblay and Pavel Hamet},
  journal={Clinical endocrinology},
  volume={73 1},
The aberrant adrenal expression and function of one or several G-protein coupled receptors can lead to cell proliferation and abnormal regulation of steroidogenesis in unilateral adenomas, carcinomas or in ACTH-independent macronodular adrenal hyperplasia (AIMAH). Excess cortisol secretion leading to either sub-clinical or overt Cushing's syndrome is the most prevalent phenotype reported to date. In a few patients, aberrant regulation of androgen excess has been reported. More recently, initial… CONTINUE READING
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Aberrant regulation of aldosterone and cortisol secretion in patients with clinical primary aldosteronism and bilateral macronodular adrenal hyperplasia

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