Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism.

@article{Qu2006AberrantFB,
  title={Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism.},
  author={Shen Qu and Jennifer Altomonte and Germ{\'a}n Perdomo and Jing Jing He and Yong Fan and Adama Kamagate and Marcia L Meseck and Hengjiang Henry Dong},
  journal={Endocrinology},
  year={2006},
  volume={147 12},
  pages={5641-52}
}
FoxO1 plays an important role in mediating the effect of insulin on hepatic metabolism. Increased FoxO1 activity is associated with reduced ability of insulin to regulate hepatic glucose production. However, the underlying mechanism and physiology remain unknown. We studied the effect of FoxO1 on the ability of insulin to regulate hepatic metabolism in normal vs. insulin-resistant liver under fed and fasting conditions. FoxO1 gain of function, as a result of adenovirus-mediated or transgenic… CONTINUE READING