Aberrant FHIT transcripts in cancerous and corresponding non-cancerous lesions of the digestive tract.

@article{Chen1997AberrantFT,
  title={Aberrant FHIT transcripts in cancerous and corresponding non-cancerous lesions of the digestive tract.},
  author={Yen-Jen Chen and Paul H. Chen and M. Douglas Lee and J. G. Chang},
  journal={International journal of cancer},
  year={1997},
  volume={72 6},
  pages={955-8}
}
The FHIT gene was recently discovered and proposed as a tumor-suppressor gene. We examined the FHIT gene in a panel of digestive-tract cancers along with their corresponding non-tumorous tissues by reverse transcription of FHIT mRNA followed by PCR amplification and sequencing of the products. A normal FHIT transcript was found to be expressed at robust levels in 44 of 46 cancerous tissues and in all of 46 non-cancerous tissues tested. Of the 46 cancerous specimens, 21 (45.7%) revealed the… CONTINUE READING
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