Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis.

Abstract

Atypical protein kinase C λ/ι (aPKCλ/ι) is a regulator of epithelial cellular polarity. It is also overexpressed in several cancers and functions in cell proliferation and invasion. Therefore, we hypothesized that aPKCλ/ι may be involved in development and progression of cervical intraepithelial neoplasia (CIN), the precancerous disease of cervical cancer… (More)
DOI: 10.1097/PGP.0000000000000228

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@article{Mizushima2016AberrantEO, title={Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis.}, author={Taichi Mizushima and Mikiko Asai-Sato and Kazunori Akimoto and Yoji Nagashima and Masataka Taguri and Kazunori Sasaki and Masa-aki Nakaya and Ryoko Asano and Aya Tokinaga and Tohru Kiyono and Fumiki Hirahara and Shigeo Ohno and Etsuko Miyagi}, journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists}, year={2016}, volume={35 2}, pages={106-17} }