Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis.

Abstract

The protein tyrosine phosphatase receptor PTPRN2 is expressed predominantly in endocrine and neuronal cells, where it functions in exocytosis. We found that its immature isoform proPTPRN2 is overexpressed in various cancers, including breast cancer. High proPTPRN2 expression was associated strongly with lymph node-positive breast cancer and poor clinical… (More)
DOI: 10.1158/0008-5472.CAN-14-2718

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@article{Sorokin2015AberrantEO, title={Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis.}, author={Alexey V. Sorokin and Binoj Chandrasekharan Nair and Y. Wei and Kathryn E. Aziz and Valentina M Evdokimova and Mien-Chie Hung and Junjie Chen}, journal={Cancer research}, year={2015}, volume={75 9}, pages={1846-58} }