Aberrant Expression of Soluble Co-stimulatory Molecules and Adhesion Molecules in Type 2 Diabetic Patients with Nephropathy

@article{Wong2007AberrantEO,
  title={Aberrant Expression of Soluble Co-stimulatory Molecules and Adhesion Molecules in Type 2 Diabetic Patients with Nephropathy},
  author={Chun Kwok Wong and Amy Wing Yin Ho and Peter Tong and C. Y. Yeung and Juliana Chung Ngor Chan and Alice P. S. Kong and C. K. Lam},
  journal={Journal of Clinical Immunology},
  year={2007},
  volume={28},
  pages={36-43}
}
Co-stimulatory molecules together with leukocyte adhesion molecules are important for T lymphocyte and leukocyte-mediated inflammatory responses. We investigated the soluble costimulatory molecules CD80, CD86, CD28, and CTLA-4 and soluble adhesion molecules in plasma of 94 type 2 diabetic patients with or without nephropathy (DN and NDN) and 20 healthy controls. Plasma concentration of sCTLA-4 was significantly lower, whereas sCD28 was significantly higher in DN patients than that in control… CONTINUE READING
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