Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease

@article{Palop2007AberrantEN,
  title={Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease},
  author={Jorge J. Palop and Jeannie Chin and Erik D Roberson and Jun Wang and Myo T. Thwin and Nga Bien-Ly and Jong W. Yoo and Kaitlyn O. Ho and G. Yu and Anatol C Kreitzer and Steven Finkbeiner and Jeffrey L Noebels and Lennart Mucke},
  journal={Neuron},
  year={2007},
  volume={55},
  pages={697-711}
}
Neural network dysfunction may play an important role in Alzheimer's disease (AD). Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein (hAPP) transgenic mice. hAPP mice with high levels of amyloid-beta peptides in the brain develop AD-like abnormalities, including cognitive deficits and depletions of calcium-related proteins in the dentate gyrus, a region critically involved in learning and memory. Here, we report that hAPP mice have spontaneous nonconvulsive… CONTINUE READING
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