Aberrant E-cadherin and gamma-catenin expression in malignant mesothelioma and its diagnostic and biological relevance.

@article{Orecchia2004AberrantEA,
  title={Aberrant E-cadherin and gamma-catenin expression in malignant mesothelioma and its diagnostic and biological relevance.},
  author={Sara Orecchia and Francesca Schillaci and Michela Salvio and Roberta Libener and P. G. Betta},
  journal={Lung cancer},
  year={2004},
  volume={45 Suppl 1},
  pages={
          S37-43
        }
}
Cadherins and their associated cytoplasmic proteins, catenins, are critical to the maintenance of normal tissue integrity and the suppression of cancer invasion. The cadherin profile in malignant mesothelioma (MM) is not well defined and the role of the cadherin-catenin system in the pathogenesis of MM remains to be determined. By means of Western blot analysis and immunohistochemistry the expression of E (epithelial)-, N (neural)-, P (placental)-cadherin, and alpha-, beta- and gamma-catenins… CONTINUE READING

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