Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression

@inproceedings{Gao2013AberrantDM,
  title={Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression},
  author={Jun Gao and Lihua Wang and Jinkang Xu and Jianming Zheng and Xiaohua Man and Hongyu Wu and Jin Jin and Kaixuan Wang and Hua-sheng Xiao and Shude Li and Zhaoshen Li},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2013}
}
BACKGROUND Altered gene methylation, regulated by DNA methyltransferases (DNMT) 1, 3a and 3b, contributes to tumorigenesis. However, the role of DNMT in pancreatic ductal adenocarcinoma (PDAC) remains unknown. METHODS Expression of DNMT 1, 3a and 3b was detected in 88 Pancreatic ductal adenocarcinoma (PDAC) and 10 normal tissue samples by immunohistochemistry. Changes in cell viability, cell cycle distribution, and apoptosis of PDAC cell lines (Panc-1 and SW1990) were assessed after… CONTINUE READING

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