Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.

@article{Jiang2009AberrantDM,
  title={Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.},
  author={Y. Jiang and A. Dunbar and L. Gondek and S. Mohan and Manjot Rataul and C. O'keefe and M. Sekeres and Y. Saunthararajah and J. Maciejewski},
  journal={Blood},
  year={2009},
  volume={113 6},
  pages={
          1315-25
        }
}
  • Y. Jiang, A. Dunbar, +6 authors J. Maciejewski
  • Published 2009
  • Biology, Medicine
  • Blood
  • Myelodysplastic syndromes (MDSs) are clonal hematologic disorders that frequently represent an intermediate disease stage before progression to acute myeloid leukemia (AML). As such, study of MDS/AML can provide insight into the mechanisms of neoplastic evolution. In 184 patients with MDS and AML, DNA methylation microarray and high-density single nucleotide polymorphism array (SNP-A) karyotyping were used to assess the relative contributions of aberrant DNA methylation and chromosomal… CONTINUE READING
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