Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.

  title={Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.},
  author={Ying Jiang and Andrew J. Dunbar and Lukasz Pawel Gondek and Sanjay Mohan and Manjot S Rataul and Christine L O'keefe and Mikkael A. Sekeres and Yogen Saunthararajah and Jaroslaw Maciejewski},
  volume={113 6},
Myelodysplastic syndromes (MDSs) are clonal hematologic disorders that frequently represent an intermediate disease stage before progression to acute myeloid leukemia (AML). As such, study of MDS/AML can provide insight into the mechanisms of neoplastic evolution. In 184 patients with MDS and AML, DNA methylation microarray and high-density single nucleotide polymorphism array (SNP-A) karyotyping were used to assess the relative contributions of aberrant DNA methylation and chromosomal… CONTINUE READING
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