Aberrant DNA methylation in lung cancer: biological and clinical implications.

@article{ZoechbauerMueller2002AberrantDM,
  title={Aberrant DNA methylation in lung cancer: biological and clinical implications.},
  author={Sabine Zoechbauer-Mueller and John D. Minna and Adi F. Gazdar},
  journal={The oncologist},
  year={2002},
  volume={7 5},
  pages={451-7}
}
Genetic abnormalities of proto-oncogenes and tumor suppressor genes are well-known changes that are frequently involved in lung cancer pathogenesis. However, another mechanism for inactivation of tumor suppressor genes is coming more and more into focus. Epigenetic inactivation of certain tumor suppressor genes by aberrant promoter methylation is frequently observed in lung carcinomas and seems to play an important role in the pathogenesis of this tumor type. While genetic abnormalities are… CONTINUE READING
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