Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours

@article{Murai2005AberrantDM,
  title={Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours},
  author={Masafumi Murai and Minoru Toyota and Ayumi Satoh and Hiroaki Suzuki and Kimishige Akino and Hiroaki Mita and Yasushi Sasaki and Tadao Ishida and Lanlan Shen and Guillermo Garcia-Manero and J-P J Issa and Yuji Hinoda and Takashi Tokino and Kohzoh Imai},
  journal={British Journal of Cancer},
  year={2005},
  volume={92},
  pages={1165 - 1172}
}
Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to better understand the role of epigenetic alteration of its expression in haematopoietic tumours. Methylation of the region around the BNIP3 transcription start site was detected in four acute… CONTINUE READING

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