Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins

  title={Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins},
  author={Go Kuratomi and Kazuya Iwamoto and Miki Bundo and Ichiro Kusumi and Norihiro Kato and Nakao Iwata and Norio Ozaki and Tadafumi Kato},
  journal={Molecular Psychiatry},
To search DNA methylation difference between monozygotic twins discordant for bipolar disorder, we applied a comprehensive genome scan method, methylation-sensitive representational difference analysis (MS-RDA) to lymphoblastoid cells derived from the twins. MS-RDA isolated 10 DNA fragments derived from 5′ region of known genes/ESTs. Among these 10 regions, four regions showed DNA methylation differences between bipolar twin and control co-twin confirmed by bisulfite sequencing. We performed a… CONTINUE READING


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