Aberrant CpG Methylation Mediates Abnormal Transcription of MAO-A Induced by Acute and Chronic l-3,4-Dihydroxyphenylalanine Administration in SH-SY5Y Neuronal Cells

@article{Yang2016AberrantCM,
  title={Aberrant CpG Methylation Mediates Abnormal Transcription of MAO-A Induced by Acute and Chronic l-3,4-Dihydroxyphenylalanine Administration in SH-SY5Y Neuronal Cells},
  author={Zhaofei Yang and Xuan Wang and Jian Yang and Min Sun and Yong Wang and Xiaomin Wang},
  journal={Neurotoxicity Research},
  year={2016},
  volume={31},
  pages={334-347}
}
l-3,4-dihydroxyphenylalanine (l-dopa) remains the most effective drug for therapy of Parkinson’s disease (PD); however, long-term use of it causes serious side effects. l-dopa-induced dyskinesia (LID) has consistently been related to l-dopa-derived excessive dopamine release, but the mechanisms have not been addressed very clear. Monoamine oxidase A (MAO-A… CONTINUE READING