Aberrant CpG Island Methylation of Multiple Genes in Ependymal Tumors

  title={Aberrant CpG Island Methylation of Multiple Genes in Ependymal Tumors},
  author={Margarita Alonso and Maria Josefa Bello and Pilar Gonz{\'a}lez-G{\'o}mez and Dolores Arjona and Jos{\'e} Marcello Salabert de Campos and Manuel S{\'a}nchez Guti{\'e}rrez and Juan Antonio Rey},
  journal={Journal of Neuro-Oncology},
Aberrant methylation of promoter CpG islands in human genes represents an alternative mechanism for genetic inactivation, and contributes to the development of human tumors. Nevertheless, thus far, few reports have analyzed methylation in ependymomas. We determined the frequency of aberrant CpG island methylation of several tumor-associated genes: p16 INK4a , RB1, MGMT, DAPK, TIMP3, THBS1, TP73, NF2 and Caspase 8 in a group of 27 ependymomas, consisting of 22 WHO grade II samples and five… CONTINUE READING


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  • Proc Natl Acad Sci USA
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