Aberrant B1 cell migration into the thymus results in activation of CD4 T cells through its potent antigen-presenting activity in the development of murine lupus.

@article{Sato2004AberrantBC,
  title={Aberrant B1 cell migration into the thymus results in activation of CD4 T cells through its potent antigen-presenting activity in the development of murine lupus.},
  author={Taku Sato and Sho Ishikawa and Kenji Akadegawa and Toshihiro Ito and Hideaki Yurino and Masahiro Kitabatake and Hiroyuki Yoneyama and Kouji Matsushima},
  journal={European journal of immunology},
  year={2004},
  volume={34 12},
  pages={
          3346-58
        }
}
B1 cells have different origin and function from conventional B (B2) cells and are considered to be involved in autoantibody production in the development of autoimmune disease. We found that B1 cells preferentially accumulated in the target organs including thymus in aged BWF1 mice, a murine model for systemic lupus erythematosus, and that B lymphocyte chemoattractant (BLC/CXCL13) expression was increased in the thymus before the onset of lupus nephritis, while stromal cell-derived factor-1… CONTINUE READING
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