Aberrant B cell development and immune response in mice with a compromised BCR complex.

@article{Torres1996AberrantBC,
  title={Aberrant B cell development and immune response in mice with a compromised BCR complex.},
  author={Ros{\'a}lia Moraes Torres and Heinrich Flaswinkel and Michael Reth and K. Rajewsky},
  journal={Science},
  year={1996},
  volume={272 5269},
  pages={1804-8}
}
The immunoglobulin alpha (Ig-alpha)-Ig-beta heterodimer is the signaling component of the antigen receptor complex on B cells (BCR) and B cell progenitors (pre-BCR). A mouse mutant that lacks most of the Ig-alpha cytoplasmic tail exhibits only a small impairment in early B cell development but a severe block in the generation of the peripheral B cell pool, revealing a checkpoint in B cell maturation that ensures the expression of a functional BCR on mature B cells. B cells that do develop… CONTINUE READING
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