Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.

@article{Rring2012AberrantBS,
  title={Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.},
  author={Michael R{\"o}ring and Tilman Brummer},
  journal={Critical reviews in oncogenesis},
  year={2012},
  volume={17 1},
  pages={97-121}
}
The Ras/Raf/MEK/ERK signaling pathway plays a key role in physiological processes and is often dysregulated in cancer as well as developmental disorders such as the neuro-cardio-facio-cutaneous syndromes. Raf proteins, and in particular B-Raf, represent an important regulatory node, which is reflected by the fact that B-Raf represents the most frequently mutated protein kinase gene in human tumors. Many genetic aberrations of the BRAF proto-oncogene, such as different point mutations and… CONTINUE READING

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