Abelson murine leukemia virus mutants with alterations in the virus-specific P120 molecule.

  title={Abelson murine leukemia virus mutants with alterations in the virus-specific P120 molecule.},
  author={Naomi E. Rosenberg and Owen N Witte},
  journal={Journal of virology},
  volume={33 1},
Abelson murine leukemia virus (A-MuLV) is a replication-defective virus that transforms both fibroblasts and hematopoietic cells in vitro. The virus encodes a 120,000-molecular-weight protein (P120) that is composed of Moloney murine leukemia virus-derived gag gene sequences and A-MuLV--specific sequences. This protein is the only A-MuLV--encoded protein that has been detected, and thus P120 is a candidate for the transforming protein of A-MuLV. We now report isolation and characterization of… CONTINUE READING

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