Abelson interactor 1 (Abi1) im kolorektalen Karzinom

  title={Abelson interactor 1 (Abi1) im kolorektalen Karzinom},
  author={Konrad Steinestel and Fenja Gl{\"a}sle and Silke Br{\"u}derlein and Julie Steinestel and C. Pr{\"o}pper and Peter M{\"o}ller},
  journal={Der Pathologe},
ZusammenfassungHintergrundInvasion und metastatische Aussaat von Tumorzellen sind beim kolorektalen Karzinom prognoseentscheidend. Abelson interactor 1 (Abi1), ein 65-kD-Substrat der Abelson-Tyrosinkinase, interagiert mit der Phosphatidylinositol-3-Kinase (PI3K) sowie dem heterogenen nukleären Ribonukleoprotein K (hnRNP K) und ist ein essenzielles Regulatorprotein zytoskelettärer Umbauvorgänge bei der Reifung synaptischer Verbindungen im zentralen Nervensystem und bei der Migration von… 

The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer

Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal cancer (CRC). ABI1 presents as at least 12 transcript variants

Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma

The DEGs between ACP patients and standard samples are found, which are likely to play an essential role in the development of ACP and are of great value in tumors’ diagnosis and targeted therapy and could even be mined as biological molecular targets for diagnosing and treating ACp patients.



Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells.

Results indicate that the Abi1 signaling plays a critical role in breast cancer progression and suggest that this pathway may serve as a therapeutic target for the treatment of human breast cancer.

Expression of Abelson Interactor 1 (Abi1) Correlates with Inflammation, KRAS Mutation and Adenomatous Change during Colonic Carcinogenesis

A role for Abi1 as a downstream target of inflammatory response and adenomatous change as well as oncogenic KRAS mutation via PI3K, but not BRAF activation is supported upon enhanced KRAS/PI3K signalling during colonic tumorigenesis.

Expression of Abl interactor 1 and its prognostic significance in breast cancer: a tissue-array-based investigation

It is demonstrated that tumors expressing high levels of Abi1 are significantly associated with early recurrence and worse survival on multivariate analysis, which suggests that Abi 1 expression has potential as a molecular marker to refine outcome prediction in breast cancer patients.

Heterogeneous Nuclear Ribonucleoprotein K Interacts with Abi-1 at Postsynaptic Sites and Modulates Dendritic Spine Morphology

Heterogeneous nuclear ribonucleoprotein K (hnRNPK), a 65 kDa ssDNA/RNA-binding-protein that is involved in multiple intracellular signaling cascades, is identified as a binding partner of Abi-1 at postsynaptic sites and shows obvious similarities regarding both protein knockdown phenotypes.

An SK3 Channel/nWASP/Abi-1 Complex Is Involved in Early Neurogenesis

Good evidence is given for a functional interplay of a trimeric complex that transforms incoming signals via SK3-channel activation into the local rearrangement of the cytoskeleton in early steps of neuronal differentiation involving nWASP and Abi-1 actin binding proteins.

Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation

Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation, and co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription.

Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.

It is shown that only ovarian cancer cell lines with LPA migratory response undergo peritoneal metastatic colonization and it is implicates that the integrity of SOS1/EPS8/ABI1 tri-complex is a determinant of ovarian cancer metastasis.

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

It is reported that Abi1, an essential component of the WAVE protein complex, also has a critical role in regulating N-WASP-dependent function and is a dual regulator of WAVE and N- WASP activities in specific processes that are dependent on actin dynamics.

Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer

In this study comparing normal colon to colorectal cancer by proteomics, hnRNP K was identified as being overexpressed in this type of cancer and Immunohistochemistry with a monoclonal antibody to hn RNP K confirmed that it was overexpressive and showed that it had an aberrant subcellular localisation in cancer cells.

Bcr-Abl induces abnormal cytoskeleton remodeling, β1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway

It is shown here that the Abi1 pathway is required for Bcr-Abl to stimulate actin cytoskeleton remodeling, integrin clustering and cell adhesion, and thatAbi1/WAVE2 is defined as a downstream pathway that contributes to Bcr -Abl-induced abnormalities of cytoskeletal and integrin function.