Abelson interactor 1 (Abi1) im kolorektalen Karzinom

@article{Steinestel2013AbelsonI1,
  title={Abelson interactor 1 (Abi1) im kolorektalen Karzinom},
  author={Konrad Steinestel and Fenja Gl{\"a}sle and Silke Br{\"u}derlein and Julie Steinestel and C. Pr{\"o}pper and Peter M{\"o}ller},
  journal={Der Pathologe},
  year={2013},
  volume={34},
  pages={189-194}
}
ZusammenfassungHintergrundInvasion und metastatische Aussaat von Tumorzellen sind beim kolorektalen Karzinom prognoseentscheidend. Abelson interactor 1 (Abi1), ein 65-kD-Substrat der Abelson-Tyrosinkinase, interagiert mit der Phosphatidylinositol-3-Kinase (PI3K) sowie dem heterogenen nukleären Ribonukleoprotein K (hnRNP K) und ist ein essenzielles Regulatorprotein zytoskelettärer Umbauvorgänge bei der Reifung synaptischer Verbindungen im zentralen Nervensystem und bei der Migration von… 
1 Citations
Abl interactor 1: A novel biomarker for osteoporosis in Chinese elderly men.
TLDR
ABI1 is a novel protein biomarker for OP in Chinese elderly and, via promoting osteoblast growth, differentiation and activity, and attenuating monocyte trans-endothelial migration and osteoclast differentiation, influences BMD variation and fracture risk in humans.

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TLDR
Results indicate that the Abi1 signaling plays a critical role in breast cancer progression and suggest that this pathway may serve as a therapeutic target for the treatment of human breast cancer.
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