Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation

  title={Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation},
  author={C. Proepper and S. Johannsen and S. Liebau and J. Dahl and B. Vaida and J. Bockmann and M. Kreutz and E. Gundelfinger and T. Boeckers},
  journal={The EMBO Journal},
  • C. Proepper, S. Johannsen, +6 authors T. Boeckers
  • Published 2007
  • Biology, Medicine
  • The EMBO Journal
  • Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a… CONTINUE READING
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