Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation

@article{Proepper2007AbelsonIP,
  title={Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation},
  author={C. Proepper and S. Johannsen and S. Liebau and J. Dahl and B. Vaida and J. Bockmann and M. Kreutz and E. Gundelfinger and T. Boeckers},
  journal={The EMBO Journal},
  year={2007},
  volume={26}
}
  • C. Proepper, S. Johannsen, +6 authors T. Boeckers
  • Published 2007
  • Biology, Medicine
  • The EMBO Journal
  • Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a… CONTINUE READING
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    References

    SHOWING 1-10 OF 55 REFERENCES
    Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
    • 202
    Postsynaptic Shank Antagonizes Dendrite Branching Induced by the Leucine-Rich Repeat Protein Densin-180
    • 98
    • PDF
    Localization and Phosphorylation of Abl-Interactor Proteins, Abi-1 and Abi-2, in the Developing Nervous System
    • 59
    • PDF
    Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
    • 200
    • PDF
    Abi1 is essential for the formation and activation of a WAVE2 signalling complex
    • 379
    Eps8 in the midst of GTPases.
    • 76
    Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons
    • 263
    • PDF