Abdominal surgery induces mu opioid receptor endocytosis in enteric neurons of the guinea-pig ileum.

@article{Patierno2004AbdominalSI,
  title={Abdominal surgery induces mu opioid receptor endocytosis in enteric neurons of the guinea-pig ileum.},
  author={Simona Patierno and Helen E. Raybould and Catia Sternini},
  journal={Neuroscience},
  year={2004},
  volume={123 1},
  pages={101-9}
}
Immunohistochemistry and confocal microscopy were used to investigate mu opioid receptor (muOR) internalization in enteric neurons of the guinea-pig ileum following abdominal surgery. The following surgical procedures were performed under halothane or isofluorane anesthesia: a) midline abdominal skin incision, b) laparotomy or c) laparotomy with intestinal manipulation. Gastrointestinal transit was evaluated by using a non-absorbable marker and measuring fecal pellet output. In neurons from… CONTINUE READING