Abdominal obesity and metabolic syndrome

@article{Desprs2006AbdominalOA,
  title={Abdominal obesity and metabolic syndrome},
  author={Jean-Pierre Despr{\'e}s and Isabelle Lemieux},
  journal={Nature},
  year={2006},
  volume={444},
  pages={881-887}
}
Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. Proposed criteria for identifying patients with metabolic syndrome have contributed greatly to preventive medicine, but the value of metabolic syndrome as a scientific concept remains controversial. The presence of metabolic syndrome alone cannot predict global cardiovascular disease risk. But abdominal… 
View on Springer
diabetes.biosino.org
3,910 Citations
Highly Influential Citations
134
Background Citations
1,558
Methods Citations
48
Results Citations
50

3,910 Citations

The Cutoff Values of Visceral Fat in Metabolic Syndrome: Evidence fromStudies

TLDR
Visceral fat is a risk factor for multiple CVD risk factors, including endothelial dysfunction, hypertension, dyslipidemia, diabetes, impaired glucose metabolism, insulin resistance), liver insulin resistance, non-alcoholic fatty liver disease, sleep apnea.

Metabolic syndrome and cardiometabolic risk factors.

TLDR
The evidence is reviewed that demonstrates that individuals with the MetS are at increased risk for CVD incidence and mortality and discusses these debated issues.

Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications

TLDR
The correlation of inflammatory disease activity with metabolic syndrome provides additional evidence for a link between inflammation and metabolic disturbances/vascular morbidity.

The metabolic syndrome

Abdominal obesity, insulin resistance, metabolic syndrome and cholesterol homeostasis

Metabolic Syndrome, Obesity Paradox and Testosterone Level

TLDR
Criticism for MetS includes its imprecise in definition, its uncertain pathogenesis as a marker of ACVD risk, and questions regarding whether this “cluster” of risk factors portend risk above and beyond the its individual components.

Metabolites in visceral fat: useful signals of metabolic syndrome?

TLDR
High-throughput metabolomics analysis of visceral fat isolated from obese individuals, with and without metabolic syndrome, and non-obese healthy controls identifies alterations in metabolic pathways that distinguish pathologically from healthy obese subjects.

Obesity and cardiovascular risk

TLDR
Obesity as an epidemic, the structural and functional changes in the cardiovascular system as a result of obesity, and the pathophysiology of obesity-related cardiomyopathy are reviewed.

The Clinical Significance of Metabolic Syndrome in Hypertension: Metabolic Syndrome Increases Cardiovascular Risk

TLDR
Management of patients with metabolic syndrome is a clinical challenge and requires a multifactorial, multidisciplinary approach, and earlier and more aggressive therapy in subjects with metabolic Syndrome will result in a future decrease in cardiovascular morbidity and mortality worldwide.

Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association

TLDR
The impact of obesity on the diagnosis, clinical management, and outcomes of atherosclerotic cardiovascular disease, heart failure, and arrhythmias, especially sudden cardiac death and atrial fibrillation are summarized.
...

References

SHOWING 1-10 OF 158 REFERENCES

Mechanisms of the metabolic syndrome

Is visceral obesity the cause of the metabolic syndrome?

TLDR
A moderate weight loss in initially abdominally obese patients is associated with a preferential mobilization of visceral adipose tissue, which in turn leads to substantial improvements in the metabolic risk profile predictive of a reduced risk of coronary heart disease and of type 2 diabetes.

Metabolic syndrome: a clinical and molecular perspective.

TLDR
Current therapies include diet and exercise as well as agents indicated for the treatment of individual components of the syndrome and future therapies may accrue from the aggressive pursuit of newer molecular drug targets that have the potential to prevent or treat multiple aspects of the metabolic syndrome.

Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds.

  • S. Grundy
  • Medicine, Biology
    Journal of the American College of Cardiology
  • 2006

Metabolic syndrome: definition, pathophysiology, and mechanisms.

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men.

TLDR
Cardiovascular disease and all-cause mortality are increased in men with the metabolic syndrome, even in the absence of baseline CVD and diabetes, according to the Kuopio Ischaemic Heart Disease Risk Factor Study.

Does a diagnosis of metabolic syndrome have value in clinical practice?

  • S. Grundy
  • Medicine, Biology
    The American journal of clinical nutrition
  • 2006
TLDR
Treating the underlying causes of the metabolic syndrome does not rule out the management of individual risk factors, but it will add strength to the control of multiple risk factors.

Obesity, regional body fat distribution, and the metabolic syndrome in older men and women.

TLDR
In addition to general obesity, the distribution of body fat is independently associated with the metabolic syndrome in older men and women, particularly among those of normal body weight.

Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus

TLDR
The metabolic syndrome accounts for up to one third of CVD in men and approximately half of new T2DM over 8 years of follow-up, and is associated with an increased risk for CVD and T2 DM in both sexes.

The metabolic syndrome: should current criteria influence clinical practice?

  • N. Sattar
  • Medicine, Biology
    Current opinion in lipidology
  • 2006
TLDR
Best evidence suggests that current metabolic syndrome criteria should not be used as an alternative to established charts for risk prediction for vascular disease, and clinical focus should remain on established risk factors to determine and reduce risk of vascular events.
...