Abdominal obesity and metabolic syndrome
@article{Desprs2006AbdominalOA, title={Abdominal obesity and metabolic syndrome}, author={Jean-Pierre Despr{\'e}s and Isabelle Lemieux}, journal={Nature}, year={2006}, volume={444}, pages={881-887} }
Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. Proposed criteria for identifying patients with metabolic syndrome have contributed greatly to preventive medicine, but the value of metabolic syndrome as a scientific concept remains controversial. The presence of metabolic syndrome alone cannot predict global cardiovascular disease risk. But abdominal…
3,866 Citations
The Cutoff Values of Visceral Fat in Metabolic Syndrome: Evidence fromStudies
- Medicine, Biology
- 2015
Visceral fat is a risk factor for multiple CVD risk factors, including endothelial dysfunction, hypertension, dyslipidemia, diabetes, impaired glucose metabolism, insulin resistance), liver insulin resistance, non-alcoholic fatty liver disease, sleep apnea.
Metabolic syndrome and cardiometabolic risk factors.
- BiologyCurrent vascular pharmacology
- 2013
The evidence is reviewed that demonstrates that individuals with the MetS are at increased risk for CVD incidence and mortality and discusses these debated issues.
Abdominal obesity, insulin resistance, metabolic syndrome and cholesterol homeostasis
- Medicine, Biology
- 2013
Metabolites in visceral fat: useful signals of metabolic syndrome?
- Biology, MedicineBiochemical Journal
- 2018
High-throughput metabolomics analysis of visceral fat isolated from obese individuals, with and without metabolic syndrome, and non-obese healthy controls identifies alterations in metabolic pathways that distinguish pathologically from healthy obese subjects.
Obesity and cardiovascular risk
- Medicine, Biology
- 2008
Obesity as an epidemic, the structural and functional changes in the cardiovascular system as a result of obesity, and the pathophysiology of obesity-related cardiomyopathy are reviewed.
The Clinical Significance of Metabolic Syndrome in Hypertension: Metabolic Syndrome Increases Cardiovascular Risk
- Medicine, Biology
- 2008
Management of patients with metabolic syndrome is a clinical challenge and requires a multifactorial, multidisciplinary approach, and earlier and more aggressive therapy in subjects with metabolic Syndrome will result in a future decrease in cardiovascular morbidity and mortality worldwide.
Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome
- Medicine, BiologyPediatric gastroenterology, hepatology & nutrition
- 2020
This review summarizes the latest concepts in the definition, pathogenesis, pathophysiology, and diagnosis of the metabolic syndrome, as well as its preventive measures and therapeutic strategies in children and adolescents.
Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association
- Medicine, BiologyCirculation
- 2021
The impact of obesity on the diagnosis, clinical management, and outcomes of atherosclerotic cardiovascular disease, heart failure, and arrhythmias, especially sudden cardiac death and atrial fibrillation are summarized.
Value of waist circumference in metabolic diseases
- Medicine, Biology
- 2012
In conclusion, waist circumference is an easily obtainable measure that can be used to quickly assess an individual’s susceptibility to cardiometabolic disease risk.
Obesity and the Metabolic Syndrome in the Elderly – A Mini-Review
- MedicineGerontology
- 2008
According to data, the identification and treatment of patients with a metabolic syndrome would be an important approach to reduce morbidity and impairments in the elderly and the various therapeutic options are summarized.
References
SHOWING 1-10 OF 183 REFERENCES
Metabolic syndrome: a clinical and molecular perspective.
- Medicine, BiologyAnnual review of medicine
- 2005
Current therapies include diet and exercise as well as agents indicated for the treatment of individual components of the syndrome and future therapies may accrue from the aggressive pursuit of newer molecular drug targets that have the potential to prevent or treat multiple aspects of the metabolic syndrome.
Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds.
- Medicine, BiologyJournal of the American College of Cardiology
- 2006
Metabolic syndrome: definition, pathophysiology, and mechanisms.
- MedicineAmerican heart journal
- 2005
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women.
- MedicineArchives of internal medicine
- 2005
In addition to general obesity, the distribution of body fat is independently associated with the metabolic syndrome in older men and women, particularly among those of normal body weight.
Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus
- Medicine, BiologyCirculation
- 2005
The metabolic syndrome accounts for up to one third of CVD in men and approximately half of new T2DM over 8 years of follow-up, and is associated with an increased risk for CVD and T2 DM in both sexes.
The metabolic syndrome: should current criteria influence clinical practice?
- Medicine, BiologyCurrent opinion in lipidology
- 2006
Best evidence suggests that current metabolic syndrome criteria should not be used as an alternative to established charts for risk prediction for vascular disease, and clinical focus should remain on established risk factors to determine and reduce risk of vascular events.
Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men
- MedicineAnnals of Internal Medicine
- 2000
A randomized, controlled trial to determine the independent effect of diet-induced or exercise-induced weight loss on obesity and insulin resistance in moderately obese men found that exercise had no independent effect on insulin sensitivity.
Metabolic syndrome and risk of cardiovascular disease: a meta-analysis.
- Medicine, BiologyThe American journal of medicine
- 2006
Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association.
- Medicine, BiologyCirculation
- 1999
This statement examines the cardiovascular complications of diabetes mellitus and considers opportunities for their prevention. These complications include coronary heart disease (CHD), stroke,…