Abbreviated kinetic profiles in area-under-the-curve monitoring of cyclosporine therapy. Technical note.

@article{Gaspari1998AbbreviatedKP,
  title={Abbreviated kinetic profiles in area-under-the-curve monitoring of cyclosporine therapy. Technical note.},
  author={Flavio Gaspari and Norberto Perico and O Signorini and Raffaele Caruso and Giuseppe Remuzzi},
  journal={Kidney international},
  year={1998},
  volume={54 6},
  pages={
          2146-50
        }
}
BACKGROUND The new microemulsion formulation of cyclosporine (CsA-ME) displays more consistent pharmacokinetic properties than the original formulation and may allow successful implementation of an abbreviated area-under-the-curve (AUC) strategy. METHODS Here we compared two limited sampling strategies in order to define the one that best predicts AUC after CsA-ME in 51 renal transplant recipients with stable renal function. Pharmacokinetics were based on analysis of blood samples collected… 
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TLDR
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Development and Validation of Limited Sampling Strategies for Estimation of Cyclosporine Area Under the Concentration–Time Curve in Hematopoietic Stem Cell Transplant Patients
TLDR
Cross-validation results showed that cyclosporine AUC0–12 h in bone marrow transplant patients could be estimated using either 2 or 3 samples within the first 4 hours after drug administration with good accuracy and precision.
Validation of Sparse Sampling Strategies to Estimate Cyclosporine A Area Under the Concentration-Time Curve Using Either a Specific Radioimmunoassay or High-Performance Liquid Chromography Method
TLDR
The validation of equations is of major importance for prediction precision, whereas the analytical method for limited sampling strategy proposals had no influence in the results.
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References

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Accurate monitoring of cyclosporine (CsA) dosage is still a problem, because measurement of the area under the curve (AUC)--the most appropriate indicator of exposure to CsA--requires a number of
Cyclosporine Monitoring in Renal Transplantation: Area Under the Curve Monitoring Is Superior to Trough‐Level Monitoring
TLDR
In renal transplant patients immunosuppressed by low doses of prednisone and CS given orally, once-a-day TL monitoring was replaced by area under the curve (AUC) monitoring, demonstrating the superiority of AUC monitoring over TL monitoring.
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This association suggests that improved cyclosporine pharmacokinetic monitoring may aid in improving outcome after kidney transplantation, and an equation is described to provide initial oral dose prediction.
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TLDR
The steady-state pharmacokinetics and tolerability of a microemulsion formulation of cyclosporine (Sandimmune Neoral) were compared with Sandimmune in 18 clinically stable renal allograft recipients and showed less variability and yielded a stronger correlation between trough concentration and systemic exposure (AUC) compared withSandimmune.
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TLDR
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TLDR
The highest AUC, Cmax and earliest Tmax values were found in patients without a T tube in situ, indicating that absorption of CyA-NOF in patients during the early course after liver transplantation is not bile-independent.
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TLDR
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TLDR
A significant negative correlation was found between the external bile drainage volume and bioavailability of cyclosporin from the microemulsion formulation, suggesting that variability in cyclosporain absorption from themicroemulsion formulations may still be at least partly attributable to bile- dependence.
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In 69 renal allograft recipients the highest-tolerated dose was given with respect to clinical events but without respect to the CsA plasma level (CsA-PL). The CsA dose was gradually decreased during
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TLDR
MeCsA appears to be a safe and effective therapy in stable renal transplant patients and provides superior and more consistent absorption of cyclosporine when compared with ConCsA, a prospective, randomized, concentration-controlled, pharmacoepidemiologic study.
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