Abatacept in the treatment of rheumatoid arthritis.

  title={Abatacept in the treatment of rheumatoid arthritis.},
  author={Derrick J Todd and Karen H Costenbader and Michael E. Weinblatt},
  journal={International journal of clinical practice},
  volume={61 3},
Over the past decade, biological immunotherapy has revolutionised the treatment of rheumatoid arthritis (RA). The most widely used of these therapies targets tumour necrosis factor-alpha (TNF-alpha). Approximately 20% of patients fail to respond to TNF-alpha antagonism, however, and a significant number of additional patients become refractory to anti-TNF-alpha therapy over time. Thus investigators have sought to target other pathogenic elements of RA using novel biological therapies. Abatacept… CONTINUE READING

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