Abatacept, a novel CD80/86-CD28 T cell co-stimulation modulator, in the treatment of rheumatoid arthritis.

@article{Korhonen2009AbataceptAN,
  title={Abatacept, a novel CD80/86-CD28 T cell co-stimulation modulator, in the treatment of rheumatoid arthritis.},
  author={Riku Korhonen and Eeva Moilanen},
  journal={Basic & clinical pharmacology & toxicology},
  year={2009},
  volume={104 4},
  pages={276-84}
}
Rheumatoid arthritis is a chronic systemic inflammatory disease with major articular manifestations. While its aetiology still remains to be resolved, our understanding on the pathogenesis of rheumatoid arthritis has become clearer during two decades enlightening the role of adaptative immunity in the development of the symptoms and signs as well as in the progression of the pathological articular changes taking place in inadequately controlled disease. T lymphocytes are considered to be an… CONTINUE READING