Abacavir: Absolute Bioavailability, Bioequivalence of Three Oral Formulations, and Effect of Food

@article{Chittick1999AbacavirAB,
  title={Abacavir: Absolute Bioavailability, Bioequivalence of Three Oral Formulations, and Effect of Food},
  author={G. Chittick and C. Gillotin and J. A. McDowell and Y. Lou and K. D. Edwards and W. Prince and D. Stein},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1999},
  volume={19}
}
  • G. Chittick, C. Gillotin, +4 authors D. Stein
  • Published 1999
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
  • Study Objectives. Study A: to determine the absolute bioavailability of a single 300‐mg abacavir hemisulfate tablet. Study B: to determine the bioequivalence of two oral abacavir formulations (300‐mg hemisulfate tablet, 100‐mg succinate caplet), the effect of food on the bioavailability of the 300‐mg hemisulfate tablet, and the bioavailability of the hemisulfate tablet relative to the hemisulfate solution. 
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    References

    SHOWING 1-10 OF 64 REFERENCES
    Food‐induced reduction in bioavailability of didanosine
    • 55
    Effects of standard breakfast on pharmacokinetics of oral zidovudine in patients with AIDS.
    • 27
    • PDF
    Pharmacokinetics and bioavailability of zidovudine in humans.
    • 121
    Pharmacokinetics of 2‘,3’‐Dideoxycytidine in Patients with AIDS and Related Disorders
    • 94