Ab ovo or de novo? Mechanisms of centriole duplication.

  title={Ab ovo or de novo? Mechanisms of centriole duplication.},
  author={Jadranka Loncarek and Alexey Khodjakov},
  journal={Molecules and cells},
  volume={27 2},
The centrosome, an organelle comprising centrioles and associated pericentriolar material, is the major microtubule organizing center in animal cells. For the cell to form a bipolar mitotic spindle and ensure proper chromosome segregation at the end of each cell cycle, it is paramount that the cell contains two and only two centrosomes. Because the number of centrosomes in the cell is determined by the number of centrioles, cells have evolved elaborate mechanisms to control centriole biogenesis… CONTINUE READING

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