Ab initio reconstruction and experimental design for cryo electron microscopy


A statistical model for the object and the complete image formation process in cryo electron microscopy of viruses is presented. Using this model, maximum-likelihood reconstructions of the three-dimensional (3-D) structure of viruses are computed using the expectation maximization algorithm, and alternative experimental designs are evaluated based on Cramer… (More)
DOI: 10.1109/18.857786

6 Figures and Tables



Citations per Year

80 Citations

Semantic Scholar estimates that this publication has 80 citations based on the available data.

See our FAQ for additional information.

  • Presentations referencing similar topics