Ab initio methods.

@article{Chivian2003AbIM,
  title={Ab initio methods.},
  author={D. Chivian and Timothy A Robertson and R. Bonneau and D. Baker},
  journal={Methods of biochemical analysis},
  year={2003},
  volume={44},
  pages={
          547-57
        }
}
Ab initio structure prediction seeks to predict the native conformation of a protein from the amino acid sequence alone. Such attempts are both a fundamental test of our understanding of protein folding, and an important practical challenge in this era of large scale genome sequencing projects, which are producing large numbers of protein sequences for which no three-dimensional structural information is available. Anfinsen showed forty years ago that all of the information necessary for a… Expand
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