Ab initio identification of human microRNAs based on structure motifs

@article{Brameier2007AbII,
  title={Ab initio identification of human microRNAs based on structure motifs},
  author={Markus Brameier and Carsten Wiuf},
  journal={BMC Bioinformatics},
  year={2007},
  volume={8},
  pages={478 - 478}
}
MicroRNAs (miRNAs) are short, non-coding RNA molecules that are directly involved in post-transcriptional regulation of gene expression. The mature miRNA sequence binds to more or less specific target sites on the mRNA. Both their small size and sequence specificity make the detection of completely new miRNAs a challenging task. This cannot be based on sequence information alone, but requires structure information about the miRNA precursor. Unlike comparative genomics approaches, ab initio… CONTINUE READING
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