Ab initio folding of proteins using restraints derived from evolutionary information.

@article{Ortiz1999AbIF,
  title={Ab initio folding of proteins using restraints derived from evolutionary information.},
  author={Angel R. Ortiz and Andrzej Kolinski and Piotr Rotkiewicz and Bartosz Ilkowski and Jeffrey Skolnick},
  journal={Proteins},
  year={1999},
  volume={Suppl 3},
  pages={
          177-85
        }
}
We present our predictions in the ab initio structure prediction category of CASP3. Eleven targets were folded, using a method based on a Monte Carlo search driven by secondary and tertiary restraints derived from multiple sequence alignments. Our results can be qualitatively summarized as follows: The global fold can be considered "correct" for targets 65 and 74, "almost correct" for targets 64, 75, and 77, "half-correct" for target 79, and "wrong" for targets 52, 56, 59, and 63. Target 72 has… CONTINUE READING
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Monte Carlo lattice dynamics and the prediction of protein folds

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