Ab initio construction of protein tertiary structures using a hierarchical approach.

@article{Xia2000AbIC,
  title={Ab initio construction of protein tertiary structures using a hierarchical approach.},
  author={Yu Xia and Enoch S. Huang and M. Levitt and Ram Samudrala},
  journal={Journal of molecular biology},
  year={2000},
  volume={300 1},
  pages={171-85}
}
We present a hierarchical method to predict protein tertiary structure models from sequence. We start with complete enumeration of conformations using a simple tetrahedral lattice model. We then build conformations with increasing detail, and at each step select a subset of conformations using empirical energy functions with increasing complexity. After enumeration on lattice, we select a subset of low energy conformations using a statistical residue-residue contact energy function, and… CONTINUE READING

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